Permeation Enhancement of Ascorbic Acid by Self-Dissolving Micropile Array Tip through Rat Skin

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Permeation enhancement of ascorbic acid by self-dissolving micropile array tip through rat skin.

Ascorbic acid (AA) loaded self-dissolving micropiles (SDMP) were prepared using chondroitin sulfate as the base for the percutaneous administration of AA. AA solution was added to dense solution of chondroitin solution, glue, and array tip, 1.0 cm(2), containing 100 SDMPs of which length was 500 microm and basal diameter was 300 microm, were prepared. Two kinds of AA array tips containing 1344....

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 2010

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.58.458